も構わず・にもかかわらず: the difference
も構わずN2
Meaning
Without worrying about
Past papers
Example
御馳走もかまわず、仕事に没頭している。
Without worrying about food, they immerse themselves in their work.
にもかかわらずN2
Meaning
Despite, In spite of, Regardless, Nevertheless
Past papers
Tested 2 times in past papers
Example
勘違いしたにもかかわらず、彼は一切謝らない。
Even though he made a mistake, he will never apologize.
How to tell them apart
「も構わず」: describes the person's attitude of not caring at all.
「にもかかわらず」: objectively, 'despite..., surprisingly...'.