N2
何しろ
なにしろ
After all, You see (giving a reason); Really, Extremely
何しろ彼はまだ始めたばかりなので大目に見てやってください。
After all, he is new, so please cut him some slack.
Explanation
「何しろ」 has 2 uses
1After all (giving the reason)
Brings in a reason that makes the result natural, usually with から or ので: 「何しろ初めてなので、大目に見てください」.
何しろ暑いからね。食欲も出ないよ。
It's so hot, you know. I've got no appetite.
何しろ彼はまだ始めたばかりなので大目に見てやってください。
After all, he is new, so please cut him some slack.
2Really, extremely (stressing degree)
With no reason clause, it just stresses how extreme something is: 「彼は何しろ謙虚だ」 (He really is modest).
あそこの会社は何しろ規律が厳しい。あれじゃあまるで軍隊だ。
That company's rules are really strict. It's practically the army.
私の父は何しろ合理的で、無駄なことを一切しません。
My father is extremely rational and never does anything pointless.