N2
それなのに
And yet, Despite this
私は毎日3時間日本語の勉強をしている。それなのに全然上達している感じがしない。
I study Japanese for three hours every day. And yet I don't feel like I'm improving at all.
Explanation
「それなのに」 starts a sentence and means 'and yet'. The first part should have led to a certain result, but the facts go the opposite way, and the speaker feels surprise, dissatisfaction or blame: 「昨日あれほど注意した。それなのに、今日も遅刻した」 (I warned him so much yesterday. And yet he was late again today). What follows is a fact that already happened, not a command, request or invitation.
Mixed up with
「それなのに」: you expected one thing and got the opposite; complaint, hurt or blame.
「それでも」: in spite of the difficulty, you keep going.
「それにしては」: by that standard the result doesn't match: 「留学していたそうだ。それにしては、あまり話せない」 (He studied abroad, they say. Even so, he can't speak much).